A return opening is the suction side of the air handler, and whatever air it can reach it will pull. In a garage that means vehicle exhaust, stored fuels, solvents and pesticides; in a mechanical closet it means the products of combustion from a furnace or water heater. Two mechanisms deliver them. The return draws directly from the space if an opening is located there, and it depressurises the space enough to reverse the natural draft of any atmospheric appliance, so flue gases spill instead of rising. Either way the contaminants enter the return and are distributed through every supply register in the house. This is why return air from garages and from rooms containing fuel-burning appliances is prohibited, and why leaky return ducts passing through those spaces produce the same result even without a deliberate opening.